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Evaluation of Antioxidant Potential and α-Amylase and α-Glucosidase Inhibitory Action of Indian Under-Utilized Fruits

Global Journal of Advanced Biological Sciences - Volume 1

Evaluation of Antioxidant Potential and α-Amylase and α-Glucosidase Inhibitory Action of Indian Under-Utilized Fruits
Global Journal of Advanced Biological Sciences

Published on 11-09-2015dA

Pages 5-11

P. Rajalakshmi1, M. Pugalenthi1 and V. Vadivel2

1Department of Botany, Government Arts College, Coimbatore, Tamilnadu, India and 2Department of CARISM, SASTRA University, Thanjavur, Tamilnadu, India

Abstract: Different parts of Tinospora cordifolia (Menispermace) and Persea americana (Lauraceae) have been used in traditional medicine for a wide range of illness and some of these uses have been proven scientifically. However, the medicinal property of fruit sample of these plants was not yet investigated. Hence the present work was carried out to evaluate the phytochemical compounds, antioxidant activity and anti-hyperglycemic potential (inhibition of α-amylase and α-glucosidase enzymes) of ethanol and aqueous extracts of fruit samples of T. cordifolia and P. americana with a view to apply them as herbal anti-diabetic drug. Ethanol and aqueous extracts were prepared from powdered fruit samples and preliminary phytochemical screening was carried out and total phenolic and flavonoid contents were quantified by spectrometric methods. Antioxidant activity of crude extracts was determined by in vitro methods (DPPH radical scavenging and reducing power assays) and α-amylase & α-glucosidase enzyme inhibitory activities of fruit extracts were analyzed using standard methodologies. The ethanolic extract of both the plants has flavonoids and terpenoids while only the presence of flavonoids was noted in aqueous extracts. Ethanol extract of P. americana fruits exhibited the highest level of antioxidant activity but possess lower levels of total phenolics and flavonoids when compared to T. cordifolia fruit extract. The aqueous and ethanolic extracts of T. cordifolia recorded remarkable inhibition activities against α-amylase and α-glucosidase enzymes, respectively. Hence, consumption of such fruits will prevent the oxidative stress and hyperglycemic complications in human beings. However, further detailed scientific investigations are necessary to prove the nutraceuticals properties of these Indian under-utilized fruits.

Keywords: Tinospora cordifolia, Persea americana, Phytochemicals, Antioxidant, α-Amylase, α-Glucosidase.

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